SCHEMBL30867018

SCHEMBL30867018

Cc1cccc(C(F)(F)F)c1C

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.48
ATM Q13315 1/20 0.48
TAS2R14 Q9NYV8 1/20 0.42
GABRA1 P14867 1/20 0.41
GABRB2 P47870 1/20 0.41
NOTUM Q6P988 1/20 0.41
HSD11B1 P28845 2/20 0.39
P2RX7 Q99572 1/20 0.38
SCN8A Q9UQD0 1/20 0.38
ALDH1A1 P00352 3/20 0.38
AR P10275 3/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
CTSS P25774 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
TSHR P16473 1/20 0.36
ACHE P22303 1/20 0.36
DHODH Q02127 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
CA1 P00915 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3821590 1.00 TRPA1 (0.48) TRPA1ATMTAS2R14GABRA1GABRB2
SCHEMBL28411326 0.88 TAS2R14 (0.40) TRPA1ATMTAS2R14GABRA1GABRB2
SCHEMBL6630838 0.87 TAS2R14 (0.46) TAS2R14NOTUMHSD11B1P2RX7ALDH1A1
SCHEMBL22827235 0.83 TRPA1 (0.46) TRPA1ATMGABRA1GABRB2SCN8A
SCHEMBL21958801 0.83 TRPA1 (0.46) TRPA1ATMGABRA1GABRB2SCN8A
SCHEMBL21994504 0.81 TRPA1 (0.44) TRPA1ATMTAS2R14GABRA1GABRB2
SCHEMBL15957667 0.81 TRPA1 (0.50) TRPA1ATMTAS2R14GABRA1GABRB2
SCHEMBL5358414 0.81 TRPA1 (0.44) TRPA1ATMTAS2R14GABRA1GABRB2
SCHEMBL18957950 0.79 TRPA1 (0.43) TRPA1ATMGABRA1GABRB2HSD11B1
SCHEMBL10022817 0.79 TRPA1 (0.43) TRPA1ATMGABRA1GABRB2HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117964544-A Synthetic method of isoindoline derivatives 上海吉奉生物科技有限公司 2024-05-03 CN disclosed