Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867709 | 0.89 | GPR119 (0.36) | KHKRAF1CCR2KCNH2 | |
| SCHEMBL38654231 | 0.88 | CCR2 (0.32) | KHKRAF1BRAFCCR2KCNH2 | |
| SCHEMBL30867891 | 0.88 | CCR2 (0.33) | KHKRAF1BRAFCCR2KCNH2 | |
| SCHEMBL38654154 | 0.85 | KHK (0.32) | KHKRAF1BRAFCCR2 | |
| SCHEMBL38654237 | 0.84 | KHK (0.32) | KHKRAF1BRAFCCR2KCNH2 | |
| SCHEMBL38654401 | 0.84 | CCR2 (0.33) | KHKRAF1BRAFCCR2KCNH2 | |
| SCHEMBL38652948 | 0.84 | CCR2 (0.33) | KHKRAF1BRAFCCR2KCNH2 | |
| SCHEMBL38653945 | 0.83 | GPR119 (0.31) | — | |
| SCHEMBL38653811 | 0.83 | GPR119 (0.30) | — | |
| SCHEMBL30867912 | 0.82 | GPR119 (0.35) | KHKRAF1BRAFHCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |