Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | HTR2B | P41595 | 2/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3087986 | 0.88 | NR1H2 (0.50) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3070016 | 0.78 | MEN1 (0.47) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL1476677 | 0.77 | HTR2C (0.59) | SMN1; SMN2MEN1KMT2AHTR2AHTR2C | |
| SCHEMBL3075374 | 0.77 | CYP19A1 (0.43) | SMN1; SMN2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1476424 | 0.75 | HTR2C (0.72) | MEN1KMT2ALMNAHTR2AHTR2C | |
| SCHEMBL4494497 | 0.74 | ALDH1A1 (0.53) | SMN1; SMN2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1475046 | 0.74 | HTR2A (0.65) | HTR2AHTR2CHTR2BNR1H3NR1H2 | |
| SCHEMBL2073851 | 0.74 | HTR7 (0.60) | SMN1; SMN2LMNAHTR2AHTR2CHTR2B | |
| SCHEMBL8025183 | 0.73 | KDM4E (0.51) | SMN1; SMN2NPC1RAB9ACYP1A2CYP3A4 | |
| SCHEMBL1475511 | 0.73 | HTR2C (0.61) | HTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795294-B2 | Tetrahydro-2H-indazole pyrazole cannabinoid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-14 | — | — | US | disclosed |