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SCHEMBL30867799

SCHEMBL30867799

CO[C@@]1(c2nccc(C)c2[C@H]2CCN(c3cc(N4C[C@@H](N5CCN(C(=O)OC(C)(C)C)CC5)[C@H]4C)nc(C(F)F)n3)[C@H](C)C2)CCOC1

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 1/20 0.30
▸ CHEK1 O14757 1/20 0.30
▸ PDCD1 Q15116 1/20 0.30
▸ CD274 Q9NZQ7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30867880 1.00 GPR119 (0.30) GPR119CHEK1PDCD1CD274
SCHEMBL30867682 1.00 GPR119 (0.30) GPR119CHEK1PDCD1CD274
SCHEMBL30867815 1.00 GPR119 (0.30) GPR119CHEK1PDCD1CD274
SCHEMBL30868005 0.92 SYK (0.32) GPR119CHEK1PDCD1CD274
SCHEMBL30867796 0.90 EGFR (0.30) —
SCHEMBL30867878 0.90 EGFR (0.30) —
SCHEMBL30867755 0.88 SYK (0.33) GPR119CHEK1PDCD1CD274
SCHEMBL30867868 0.88 SYK (0.33) GPR119CHEK1PDCD1CD274
SCHEMBL30868030 0.88 SYK (0.33) GPR119CHEK1PDCD1CD274
SCHEMBL30867725 0.88 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598917-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF Amgen Inc. (US) 2025-08-13 — — EP disclosed
WO-2024076674-A1 HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF AMGEN INC. (US) 2024-04-11 — — WO disclosed