Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.32 |
| ▸ | EIF2AK4 | Q9P2K8 | 3/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.30 |
| ▸ | P2RX2 | Q9UBL9 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867868 | 1.00 | SYK (0.33) | SYKGPR119CHEK1PDCD1CD274 | |
| SCHEMBL30867755 | 1.00 | SYK (0.33) | SYKGPR119CHEK1PDCD1CD274 | |
| SCHEMBL30868005 | 0.96 | SYK (0.32) | SYKGPR119CHEK1PDCD1CD274 | |
| SCHEMBL30867709 | 0.92 | GPR119 (0.36) | SYKGPR119EIF2AK4USP30DDB1 | |
| SCHEMBL30867694 | 0.90 | CCR2 (0.30) | CHEK1PDCD1CD274HCRTR1HCRTR2 | |
| SCHEMBL30867912 | 0.89 | GPR119 (0.35) | SYKGPR119EIF2AK4USP30DDB1 | |
| SCHEMBL30867847 | 0.88 | EIF2AK4 (0.34) | SYKGPR119CHEK1PDCD1CD274 | |
| SCHEMBL30867682 | 0.88 | GPR119 (0.30) | GPR119CHEK1PDCD1CD274 | |
| SCHEMBL30867815 | 0.88 | GPR119 (0.30) | GPR119CHEK1PDCD1CD274 | |
| SCHEMBL30867897 | 0.88 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |