Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 3/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30867792 | 0.83 | PROKR1 (0.35) | PROKR1 | |
| SCHEMBL30868022 | 0.77 | PDE2A (0.38) | — | |
| SCHEMBL31543517 | 0.74 | ALOX5 (0.38) | ALOX5TYK2JAK2 | |
| SCHEMBL26685461 | 0.74 | ALOX5 (0.38) | ALOX5TYK2JAK2 | |
| SCHEMBL29546485 | 0.72 | TYK2 (0.41) | ALOX5TYK2JAK2 | |
| Hydrochloric Acid SCHEMBL30867700 | 0.71 | — | — | |
| SCHEMBL30173038 | 0.70 | ALOX5 (0.36) | ALOX5TYK2 | |
| SCHEMBL30867973 | 0.70 | ALOX5 (0.31) | ALOX5 | |
| SCHEMBL29239381 | 0.70 | ALOX5 (0.41) | ALOX5TYK2 | |
| SCHEMBL30867695 | 0.69 | PDE2A (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598917-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024076674-A1 | HETEROCYCLIC INHIBITORS OF KRAS G12C MUTANT PROTEINS AND USES THEREOF | AMGEN INC. (US) | 2024-04-11 | — | — | WO | disclosed |