Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 10/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27170903 | 1.00 | CYP17A1 (0.47) | CYP17A1SCN9AICAM1SELEL3MBTL1 | |
| SCHEMBL27170906 | 0.89 | SCN9A (0.47) | SCN9A | |
| SCHEMBL30868558 | 0.89 | SCN9A (0.47) | SCN9A | |
| SCHEMBL30868536 | 0.78 | ICAM1 (0.39) | SCN9AICAM1SELETEAD1YAP1 | |
| SCHEMBL27170919 | 0.78 | BRD4 (0.39) | TEAD1YAP1 | |
| SCHEMBL24631284 | 0.78 | ICAM1 (0.39) | SCN9AICAM1SELETEAD1YAP1 | |
| SCHEMBL30868593 | 0.78 | BRD4 (0.39) | TEAD1YAP1 | |
| SCHEMBL27170917 | 0.77 | BRD4 (0.45) | L3MBTL1 | |
| SCHEMBL30868540 | 0.77 | BRD4 (0.45) | L3MBTL1 | |
| SCHEMBL24631290 | 0.76 | PTPN2 (0.52) | TEAD1YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | CYP17A1 352/4885SCN9A 353/4885ICAM1 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.