Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27170906 | 1.00 | SCN9A (0.47) | SCN9ASCN5ATRPV1EPHX2BRD4 | |
| SCHEMBL27170903 | 0.89 | CYP17A1 (0.47) | SCN9A | |
| SCHEMBL30868534 | 0.89 | CYP17A1 (0.47) | SCN9A | |
| SCHEMBL30868540 | 0.79 | BRD4 (0.45) | BRD4 | |
| SCHEMBL27170917 | 0.79 | BRD4 (0.45) | BRD4 | |
| SCHEMBL24631356 | 0.79 | TNNI3K (0.49) | SCN9ASCN5ABRD4 | |
| SCHEMBL30868609 | 0.79 | TNNI3K (0.49) | SCN9ASCN5ABRD4 | |
| SCHEMBL22559254 | 0.77 | L3MBTL1 (0.48) | SCN9ASCN5A | |
| SCHEMBL29754996 | 0.77 | L3MBTL1 (0.48) | SCN9ASCN5A | |
| SCHEMBL30868560 | 0.76 | BRAF (0.38) | SCN9ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240083903-A1 | ARYL ETHER COMPOUNDS AS TEAD MODULATORS | TEAD2, TEAD3, TEAD4 | SCN9A 353/4885SCN5A 227/4885TRPV1 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.