Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metrizoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metrizoic Acid SCHEMBL1237977 | 1.00 | SMN1; SMN2 (0.78) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Metrizoic Acid SCHEMBL2339916 | 0.99 | SMN1; SMN2 (0.76) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Diatrizoic Acid SCHEMBL107036 | 0.88 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL1685085 | 0.88 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL720469 | 0.88 | SMN1; SMN2 (1.00) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL468613 | 0.87 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Diatrizoic Acid SCHEMBL2501947 | 0.87 | SMN1; SMN2 (0.97) | SMN1; SMN2LMNAKDM4EHIF1ACYP1A2 | |
| Iothalamic Acid SCHEMBL29488709 | 0.83 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL180546 | 0.83 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 | |
| Iothalamic Acid SCHEMBL48785 | 0.83 | SMN1; SMN2 (0.84) | SMN1; SMN2LMNAKDM4EHIF1ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3741381-B1 | A PEPTIDE FOR USE FOR PREVENTION AND TREATMENT OF ACUTE RENAL INJURY | UNIV CORNELL (US) | 2024-04-24 | — | — | EP | disclosed |