Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28502106 | 1.00 | POLB (0.45) | POLBNLRP3GRM4NAMPTTP53 | |
| SCHEMBL30870533 | 0.89 | POLB (0.44) | POLBNLRP3GRM4NAMPTTP53 | |
| SCHEMBL29198166 | 0.89 | POLB (0.44) | POLBNLRP3GRM4NAMPTTP53 | |
| SCHEMBL29198168 | 0.89 | POLB (0.44) | POLBNLRP3GRM4NAMPTTP53 | |
| SCHEMBL29198258 | 0.87 | POLB (0.43) | POLBNLRP3GRM4NAMPTACHE | |
| SCHEMBL30870547 | 0.85 | EGFR (0.43) | POLBNLRP3GRM4TP53MTNR1A | |
| SCHEMBL28512461 | 0.85 | MAPT (0.49) | POLBACHEBACE1MAPTLMNA | |
| SCHEMBL30870559 | 0.85 | MAPT (0.49) | POLBACHEBACE1MAPTLMNA | |
| SCHEMBL29198178 | 0.85 | EGFR (0.43) | POLBNLRP3GRM4TP53MTNR1A | |
| SCHEMBL30870543 | 0.83 | POLB (0.40) | POLBNLRP3GRM4ACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112074511-B | Substituted benzodiazoles and their use in therapy | 托马斯·黑勒戴药物研究基金会 | 2024-04-26 | — | — | CN | disclosed |