Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | LPAR5 | Q9H1C0 | 2/20 | 0.32 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.32 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.32 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.32 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.32 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.32 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.32 |
| ▸ | PGK1 | P00558 | 1/20 | 0.31 |
| ▸ | PGK2 | P07205 | 1/20 | 0.31 |
| ▸ | PGD | P52209 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL15324171 | 0.85 | CA4 (0.48) | SMN1; SMN2CA4 | |
| Choline SCHEMBL1009005 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2LPAR5LPAR6LPAR1LPAR4 | |
| Choline SCHEMBL29876695 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2LPAR5LPAR6LPAR1LPAR4 | |
| Citric Acid SCHEMBL15324247 | 0.81 | CA4 (0.37) | SMN1; SMN2CA4 | |
| Citric Acid SCHEMBL275858 | 0.79 | CA4 (0.59) | CA4 | |
| Citric Acid SCHEMBL20456925 | 0.79 | CA4 (0.59) | CA4 | |
| Citric Acid SCHEMBL692736 | 0.79 | CA4 (0.59) | CA4 | |
| Citric Acid SCHEMBL119893 | 0.79 | CA4 (0.59) | CA4 | |
| Citric Acid SCHEMBL3871318 | 0.77 | CA4 (0.57) | CA4 | |
| Citric Acid SCHEMBL15323424 | 0.77 | CA4 (0.57) | CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111407721-B | System for promoting active ingredient to permeate skin | 复旦大学 | 2024-04-30 | — | — | CN | disclosed |