Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 6/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18828724 | 0.89 | NAMPT (0.43) | NAMPTCNR2KDM4EKMT2ALTA4H | |
| SCHEMBL29640169 | 0.88 | KDM4E (0.38) | NAMPTKDM4EKMT2ACYP1A2HRH3 | |
| SCHEMBL31751854 | 0.86 | LTA4H (0.34) | LTA4H | |
| SCHEMBL26926486 | 0.84 | TSHR (0.33) | LTA4H | |
| SCHEMBL700399 | 0.82 | NAMPT (0.41) | NAMPTCNR2CYP1A2CA2CHKA | |
| SCHEMBL31599560 | 0.79 | LTA4H (0.31) | LTA4H | |
| SCHEMBL20791651 | 0.77 | LTA4H (0.32) | LTA4H | |
| SCHEMBL29711975 | 0.77 | NAMPT (0.34) | NAMPTKDM4EKMT2A | |
| SCHEMBL18320297 | 0.77 | NAMPT (0.38) | NAMPTCNR2CYP1A2CA2CHKA | |
| SCHEMBL27158320 | 0.77 | NAMPT (0.38) | NAMPTCNR2KDM4EKMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4568951-A1 | HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2025-06-18 | — | — | EP | disclosed |
| WO-2024035627-A1 | HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS | AJAX THERAPEUTICS, INC. (US) | 2024-02-15 | — | — | WO | disclosed |