Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.55 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.55 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.55 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.53 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.52 |
| ▸ | ACLY | P53396 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300608 | 0.78 | SMO (0.71) | HPGDCYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL30370145 | 0.78 | HDAC1 (0.71) | HPGDMAPTRAB9AKMT2ANPC1 | |
| SCHEMBL1308014 | 0.77 | HPGD (0.68) | HPGDCYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL11578739 | 0.77 | KCNK3 (0.68) | HPGDMAPTLMNARAB9AKMT2A | |
| SCHEMBL15779461 | 0.77 | MAPT (0.59) | HPGDMAPTKDM4EALDH1A1LMNA | |
| SCHEMBL6847222 | 0.77 | HPGD (0.58) | HPGDCYP1A2CYP2C19MAPTKDM4E | |
| SCHEMBL28598714 | 0.76 | CYP1A2 (0.62) | HPGDCYP1A2CYP2C19MAPTRAB9A | |
| SCHEMBL9352497 | 0.75 | KMT2A (0.55) | MAPTLMNARAB9AKMT2ANPC1 | |
| SCHEMBL6362508 | 0.75 | HPGD (0.50) | HPGDCYP1A2CYP2C19KDM4EALDH1A1 | |
| SCHEMBL5445940 | 0.75 | ALDH1A1 (0.62) | HPGDMAPTKDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118126043-B | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2025-01-28 | — | — | CN | claimed |
| WO-2024114574-A1 | HIGH-SELECTIVITY PLK4 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2024-06-06 | — | — | WO | claimed |
| CN-118126043-A | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2024-06-04 | — | — | CN | claimed |
| CN-118126043-B | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2025-01-28 | — | — | CN | disclosed |
| WO-2024114574-A1 | HIGH-SELECTIVITY PLK4 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 沈阳药科大学 | 2024-06-06 | — | — | WO | disclosed |
| CN-118126043-A | PLK4 inhibitor with high selectivity and preparation method and application thereof | 沈阳药科大学 | 2024-06-04 | — | — | CN | disclosed |