Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877495 | 0.84 | RAPGEF4 (0.48) | RAPGEF4ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL30877347 | 0.82 | CYP3A4 (0.38) | CYP2C19CYP3A4ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL30877247 | 0.75 | RAPGEF4 (0.51) | RAPGEF4ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL30041811 | 0.72 | HTR6 (0.53) | RAPGEF4ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL30877392 | 0.72 | RAPGEF4 (0.48) | RAPGEF4ALDH1A1L3MBTL1SMN1; SMN2MAPT | |
| SCHEMBL17809691 | 0.71 | CYP2C19 (0.49) | CYP2C19CYP3A4ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28449000 | 0.70 | RAPGEF4 (0.51) | RAPGEF4CYP3A4ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL28456542 | 0.70 | RAPGEF4 (0.51) | RAPGEF4ALDH1A1L3MBTL1LMNAMEN1 | |
| SCHEMBL25425550 | 0.69 | RAPGEF4 (0.50) | RAPGEF4ALDH1A1L3MBTL1MAPTCA1 | |
| SCHEMBL7678499 | 0.69 | RAPGEF4 (0.56) | RAPGEF4ALDH1A1L3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964643-B | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-117964643-A | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-05-03 | — | — | CN | disclosed |