Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877400 | 0.90 | RAPGEF4 (0.40) | RAPGEF4ALDH1A1L3MBTL1MAPTHTR6 | |
| SCHEMBL30877298 | 0.90 | RAPGEF4 (0.40) | RAPGEF4JAK2JAK1TYK2JAK3 | |
| SCHEMBL30877398 | 0.84 | TTK (0.35) | JAK2JAK1TYK2JAK3TTK | |
| SCHEMBL30877450 | 0.82 | RAPGEF4 (0.41) | RAPGEF4KDM4EALDH1A1HPGDKMT2A | |
| SCHEMBL30877275 | 0.80 | RAPGEF4 (0.45) | RAPGEF4KDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30877318 | 0.79 | RAPGEF4 (0.44) | RAPGEF4KDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30877392 | 0.79 | RAPGEF4 (0.48) | RAPGEF4KDM4EALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL30877498 | 0.78 | RAPGEF4 (0.43) | RAPGEF4JAK2JAK1TYK2JAK3 | |
| SCHEMBL30877418 | 0.78 | RAPGEF4 (0.43) | RAPGEF4JAK2JAK1TYK2JAK3 | |
| SCHEMBL30877504 | 0.78 | RAPGEF4 (0.43) | RAPGEF4JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117964643-B | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-117964643-A | Pyrrole [2,3-b ] pyridine derivative and preparation method and application thereof | 苏州朗睿生物医药有限公司 | 2024-05-03 | — | — | CN | disclosed |