SCHEMBL30878322

SCHEMBL30878322

C=Cc1c(-c2ccccc2Cl)c(=O)n(C)c2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc12

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 6/20 0.59
MAP3K7 O43318 1/20 0.58
TNK2 Q07912 5/20 0.58
SRC P12931 3/20 0.58
IGF1R P08069 5/20 0.57
ALK Q9UM73 5/20 0.57
INSR P06213 3/20 0.57
AXL P30530 1/20 0.55
GAK O14976 1/20 0.54
DCLK1 O15075 1/20 0.54
BRD4 O60885 1/20 0.54
MAPK7 Q13164 1/20 0.54
TNK1 Q13470 1/20 0.54
LRRK2 Q5S007 1/20 0.54
DCLK2 Q8N568 1/20 0.54
JAK2 O60674 1/20 0.53
PTK2 Q05397 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30878354 0.88 IGF1R (0.60) EGFRMAP3K7TNK2SRCIGF1R
SCHEMBL30878347 0.87 EGFR (0.61) EGFRSRCIGF1RALKINSR
SCHEMBL30878475 0.86 SRC (0.63) MAP3K7SRCALK
SCHEMBL30878685 0.83 IGF1R (0.54) EGFRMAP3K7TNK2SRCIGF1R
SCHEMBL30878310 0.79 EGFR (0.65) EGFRSRCIGF1RALKINSR
SCHEMBL30878358 0.77 FGFR1 (0.64) EGFRSRC
SCHEMBL31557219 0.75 WEE1 (0.75) EGFRIGF1RALKINSR
SCHEMBL12004461 0.75 WEE1 (0.75) EGFRIGF1RALKINSR
SCHEMBL30878488 0.75 EGFR (0.53) EGFRIGF1RLRRK2JAK2PTK2
SCHEMBL30878461 0.74 FGFR1 (0.63) EGFRSRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP claimed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO claimed
EP-4612148-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER Cancer Research Technology Limited (GB) 2025-09-10 EP disclosed
WO-2024094963-A1 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2024-05-10 WO disclosed