Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.61 |
| ▸ | WEE1 | P30291 | 3/20 | 0.55 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 1/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.44 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878310 | 0.92 | EGFR (0.65) | EGFRFGFR1WEE1IGF1RLRRK2 | |
| SCHEMBL30878488 | 0.87 | EGFR (0.53) | EGFRFGFR1WEE1IGF1RLRRK2 | |
| SCHEMBL30878322 | 0.87 | EGFR (0.59) | EGFRIGF1RLRRK2ALKPTK2 | |
| SCHEMBL30878358 | 0.86 | FGFR1 (0.64) | EGFRFGFR1WEE1SRC | |
| SCHEMBL30878397 | 0.85 | EGFR (0.64) | EGFRFGFR1WEE1IGF1RLRRK2 | |
| SCHEMBL30878805 | 0.79 | EGFR (0.56) | EGFRFGFR1WEE1IGF1RLRRK2 | |
| SCHEMBL30878501 | 0.78 | FGFR1 (0.53) | EGFRFGFR1WEE1SRC | |
| SCHEMBL30878459 | 0.78 | ABL1 (0.65) | EGFRFGFR1WEE1SRC | |
| SCHEMBL30878475 | 0.78 | SRC (0.63) | FGFR1WEE1ALKLCKSRC | |
| SCHEMBL30878382 | 0.78 | WEE1 (0.70) | EGFRFGFR1WEE1IGF1RLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | claimed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | claimed |
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |