Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.65 |
| ▸ | SRC | P12931 | 8/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.65 |
| ▸ | EGFR | P00533 | 5/20 | 0.65 |
| ▸ | KIT | P10721 | 1/20 | 0.65 |
| ▸ | WEE1 | P30291 | 6/20 | 0.58 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.51 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878448 | 0.92 | ABL1 (0.68) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878311 | 0.86 | SRC (0.67) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878358 | 0.86 | FGFR1 (0.64) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30879263 | 0.81 | ABL1 (0.59) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878456 | 0.80 | ABL1 (0.70) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL29931141 | 0.79 | FGFR1 (1.00) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL29658884 | 0.79 | FGFR1 (1.00) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL256710 | 0.79 | FGFR1 (1.00) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878332 | 0.79 | WEE1 (0.56) | ABL1SRCPDGFRBPDGFRAMAPK14 | |
| SCHEMBL30878347 | 0.78 | EGFR (0.61) | SRCFGFR1EGFRWEE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | claimed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | claimed |
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |