Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 1/20 | 0.59 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.58 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.54 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.54 |
| ▸ | INSR | P06213 | 2/20 | 0.53 |
| ▸ | IGF1R | P08069 | 2/20 | 0.53 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.53 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30878718 | 0.92 | ZAP70 (0.59) | ZAP70PTK2RAB9AKDM4EALDH1A1 | |
| SCHEMBL30878826 | 0.88 | CYP1A2 (0.62) | AKR1C3AKR1C2RAB9AMAPK1EGFR | |
| SCHEMBL30879241 | 0.88 | GAA (0.58) | AKR1C3AKR1C2PTK2RAB9AALDH1A1 | |
| SCHEMBL30879227 | 0.85 | RAB9A (0.62) | PTK2RAB9AEGFRMAP4K1ALK | |
| SCHEMBL14658247 | 0.83 | MAPK8 (0.71) | EGFRMAP4K1MAPK8SHMT2 | |
| SCHEMBL29761515 | 0.83 | MAPK8 (0.71) | EGFRMAP4K1MAPK8SHMT2 | |
| SCHEMBL30878841 | 0.83 | KMT2A (0.64) | ZAP70AKR1C3AKR1C2PTK2RAB9A | |
| SCHEMBL31612071 | 0.82 | SHMT2 (0.53) | AKR1C3AKR1C2PTK2KDM4EALDH1A1 | |
| SCHEMBL30878806 | 0.82 | F12 (0.52) | ZAP70PTK2RAB9AKDM4EALDH1A1 | |
| SCHEMBL30879169 | 0.81 | RAB9A (0.65) | PTK2RAB9AKDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |