Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879301 | 0.80 | MAPT (0.37) | MEN1KMT2AMAPTSLC6A2CACNA2D1 | |
| SCHEMBL30879246 | 0.75 | FGFR4 (0.36) | MEN1KMT2AMAPTKDM4EFGFR4 | |
| SCHEMBL30879072 | 0.74 | STK4 (0.38) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL30878982 | 0.72 | RPS6KA5 (0.37) | MEN1KMT2AMAPTKDM4EHPGD | |
| SCHEMBL17070921 | 0.70 | KDM4E (0.69) | KDM4CMEN1KMT2ACES2ALDH1A1 | |
| SCHEMBL30879206 | 0.69 | FGFR4 (0.40) | MEN1KMT2AMAPTSLC6A2CACNA2D1 | |
| SCHEMBL7590747 | 0.68 | MAPT (0.36) | MEN1KMT2AMAPTSLC6A2CACNA2D1 | |
| SCHEMBL4435666 | 0.66 | KMT2A (0.72) | KDM4CMEN1KMT2ACES2MAPT | |
| SCHEMBL27265278 | 0.65 | FGFR4 (0.53) | MAPTSLC6A2CACNA2D1ALDH1A1KDM4E | |
| SCHEMBL3528616 | 0.65 | SLC6A2 (0.41) | MEN1KMT2AMAPTSLC6A2CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |