Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.63 |
| ▸ | USP2 | O75604 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.51 |
| ▸ | SYK | P43405 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30879124 | 0.94 | MAPT (0.70) | SIRT5ALOX15TSHRNPSR1MAPT | |
| SCHEMBL30878914 | 0.93 | MAPT (0.60) | SIRT5ALOX15TSHRNPSR1MAPT | |
| SCHEMBL30878883 | 0.91 | SIRT5 (0.60) | SIRT5ALOX15TSHRNPSR1MAPT | |
| SCHEMBL30879227 | 0.87 | RAB9A (0.62) | RAB9AMAPK8MAPK9EGFRAURKA | |
| SCHEMBL14658264 | 0.85 | MAPK8 (0.74) | RAB9AMAPK8MAPK9EGFRMAP4K1 | |
| SCHEMBL29761528 | 0.85 | MAPK8 (0.74) | RAB9AMAPK8MAPK9EGFRMAP4K1 | |
| SCHEMBL30879121 | 0.84 | RAB9A (0.50) | SIRT5ALOX15TSHRNPSR1MAPT | |
| SCHEMBL18011900 | 0.81 | MAP4K1 (0.49) | SIRT5ALOX15TSHRNPSR1MAPT | |
| SCHEMBL29526267 | 0.81 | MAP4K1 (0.80) | MAP4K1 | |
| SCHEMBL30879241 | 0.81 | GAA (0.58) | NPSR1MAPTSMN1; SMN2RAB9AMAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612148-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | Cancer Research Technology Limited (GB) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024094963-A1 | 2-AMINO-PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE AND 7-AMINO-1-PYRIMIDO[4,5-D]PYRIMIDIN-2(1 H)-ONE DERIVATIVES AS EGFR INHIBITORS FOR THE TREATMENT OF CANCER | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2024-05-10 | — | — | WO | disclosed |