Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bezafibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 12/20 | 0.98 |
| ▸ | PPARG known ✓ | P37231 | 3/20 | 0.98 |
| ▸ | PPARD known ✓ | Q03181 | 3/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.98 |
| ▸ | FABP2 | P12104 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bezafibrate SCHEMBL5077755 | 0.99 | PPARA (1.00) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL16299 | 0.99 | PPARA (1.00) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL28565716 | 0.98 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL22364278 | 0.98 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL15156489 | 0.94 | PPARA (0.91) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL12690942 | 0.89 | PPARA (0.82) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL1304559 | 0.88 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL14017691 | 0.88 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL22943060 | 0.88 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL13169312 | 0.88 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100234402-A1 | METHODS AND COMPOSITIONS FOR TREATING SPINAL MUSCULAR ATROPHY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA | 2010-09-16 | — | — | US | disclosed |
| WO-2008150509-A1 | METHODS AND COMPOSITIONS FOR TREATING SPINAL MUSCULAR ATROPHY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2008-12-11 | — | — | WO | disclosed |