Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bezafibrate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA known ✓ | Q07869 | 13/20 | 1.00 |
| ▸ | PPARG known ✓ | P37231 | 3/20 | 1.00 |
| ▸ | PPARD known ✓ | Q03181 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | FABP2 | P12104 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bezafibrate SCHEMBL16299 | 1.00 | PPARA (1.00) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL28565716 | 0.99 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL22364278 | 0.99 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL3088387 | 0.99 | PPARA (0.98) | PPARAPPARGPPARDALDH1A1FABP2 | |
| Bezafibrate SCHEMBL15156489 | 0.95 | PPARA (0.91) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL12690942 | 0.90 | PPARA (0.82) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL1304559 | 0.89 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL14017691 | 0.89 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL22943060 | 0.89 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 | |
| SCHEMBL13169312 | 0.89 | PPARA (0.80) | PPARAPPARGPPARDALDH1A1FABP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114195672-A | Amide prodrugs of small molecule nuclear receptor modulators | 俄勒冈健康科学大学 | 2022-03-18 | — | — | CN | disclosed |
| CN-111801013-B | Amide prodrugs of small molecule nuclear receptor modulators | 俄勒冈健康科学大学 | 2021-12-24 | — | — | CN | disclosed |
| CN-111801013-A | Amide prodrugs of small molecule nuclear receptor modulators | 俄勒冈健康科学大学 | 2020-10-20 | — | — | CN | disclosed |
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| EP-3062782-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2016-09-07 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-2914252-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | Pharnext (FR) | 2015-09-09 | — | — | EP | disclosed |
| EP-2892518-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | Pharnext (FR) | 2015-07-15 | — | — | EP | disclosed |
| WO-2015063140-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2015-05-07 | — | — | WO | disclosed |
| WO-2014068007-A1 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETES AND RELATED CONDITIONS BY CONTROLLING BLOOD GLUCOSE LEVEL | PHARNEXT (FR) | 2014-05-08 | — | — | WO | disclosed |
| WO-2014037416-A2 | NEW THERAPEUTIC APPROACHES FOR TREATING PARKINSON'S DISEASE | PHARNEXT (FR) | 2014-03-13 | — | — | WO | disclosed |
| EP-1781303-A4 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX INC (US) | 2008-07-02 | — | — | EP | disclosed |
| EP-1781303-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | CombinatoRx, Incorporated (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006004803-A1 | METHODS AND REAGENTS FOR THE TREATMENT OF METABOLIC DISORDERS | COMBINATORX, INCORPORATED (US) | 2006-01-12 | — | — | WO | disclosed |