4,4'-Methylenedianiline

4,4'-Methylenedianiline

SCHEMBL3088397

Nc1ccc(Cc2ccc(N)cc2)cc1.Nc1ccc(Oc2ccc(N)cc2)cc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.70
TDP1 Q9NUW8 3/20 0.70
CYP3A4 P08684 3/20 0.70
TSHR P16473 2/20 0.70
MAOA P21397 2/20 0.58
MAPT P10636 5/20 0.56
TEAD4 Q15561 1/20 0.56
MAOB P27338 1/20 0.56
SMN1; SMN2 Q16637 2/20 0.54
GFER P55789 2/20 0.54
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
POLB P06746 1/20 0.54
MITF O75030 1/20 0.54
GAA P10253 1/20 0.54
NLRP1 Q9C000 1/20 0.54
NOD2 Q9HC29 1/20 0.54
NPC1 O15118 3/20 0.50
RAB9A P51151 3/20 0.50
HPGD P15428 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6367807 1.00 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL309399 1.00 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL26840183 1.00 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL8846558 1.00 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL26840176 1.00 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL14088680 0.93 ALDH1A1 (0.61) ALDH1A1TDP1CYP3A4TSHRMAOA
4,4'-Methylenedianiline SCHEMBL29016440 0.91 MAOA (0.75) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL8732491 0.91 MAOA (0.68) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL13139577 0.89 TEAD4 (0.76) ALDH1A1TDP1CYP3A4TSHRMAOA
SCHEMBL309841 0.85 ALDH1A1 (0.70) ALDH1A1TDP1CYP3A4TSHRMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7794917-B2 Curable composition, color filter and manufacturing method thereof FUJIFILM CORPORATION (JP) 2010-09-14 US disclosed
EP-2152660-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP Rolic AG (CH) 2010-02-17 EP disclosed
WO-2008145225-A2 PHOTOCROSSLINKABLE MATERIALS COMPRISING ALICYCLIC GROUP ROLIC AG (CH) 2008-12-04 WO disclosed
US-20080076043-A1 CURABLE COMPOSITION, COLOR FILTER AND MANUFACTURING METHOD THEREOF FUJIFILM CORPORATION (JP) 2008-03-27 US disclosed
US-4511535-A Liquid monomer feed pipe for continuous extrusion polymerization GENERAL ELECTRIC COMPANY (US) 1985-04-16 US disclosed
EP-0120183-A2 Continuous process for preparing polyetherimides GENERAL ELECTRIC COMPANY (US) 1984-10-03 EP disclosed
EP-0120184-A2 Continuous process for preparing polyetherimides GENERAL ELECTRIC COMPANY (US) 1984-10-03 EP disclosed
EP-0117395-A2 Liquid monomer feed pipe for continuous extrusion polymerization GENERAL ELECTRIC COMPANY (US) 1984-09-05 EP disclosed
US-4443592-A MELTS, KNEADING, SHEAR GENERAL ELECTRIC COMPANY (US) 1984-04-17 US disclosed