Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17648740 | 0.83 | HSD17B10 (0.43) | ALDH1A1CYP2C9HTTTDP1HSD17B10 | |
| SCHEMBL21244672 | 0.80 | ALDH1A1 (0.51) | ALDH1A1CYP2C9METAP1HTTTDP1 | |
| SCHEMBL26662403 | 0.80 | ALDH1A1 (0.42) | ALDH1A1CYP2C9METAP1HTTTDP1 | |
| SCHEMBL30928671 | 0.80 | ALDH1A1 (0.51) | ALDH1A1METAP1HTTTDP1HSD17B10 | |
| SCHEMBL30821924 | 0.77 | POLB (0.44) | HSD17B10SMN1; SMN2NPC1RAB9ADRD2 | |
| SCHEMBL22280430 | 0.74 | MEN1 (0.62) | ALDH1A1CYP2C9HTTCTSBLMNA | |
| SCHEMBL30646274 | 0.72 | ALDH1A1 (0.59) | ALDH1A1CYP2C9METAP1HTTTDP1 | |
| SCHEMBL9364221 | 0.71 | ALDH1A1 (0.47) | ALDH1A1CYP2C9METAP1HTTTDP1 | |
| SCHEMBL31735945 | 0.71 | LMNA (0.48) | ALDH1A1CYP2C9METAP1HTTTDP1 | |
| SCHEMBL30821620 | 0.69 | KCNQ3 (0.44) | ALDH1A1CYP2C9HTTHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4611899-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | Petra Pharma Corporation (US) | 2025-09-10 | — | — | EP | disclosed |
| US-20250206752-A1 | PI3K INHIBITORS | COGENT BIOSCIENCES, INC. | 2025-06-26 | — | — | US | disclosed |
| US-12281122-B1 | PI3K inhibitors | COGENT BIOSCIENCES, INC. (US) | 2025-04-22 | — | — | US | disclosed |
| WO-2025029683-A1 | PI3K INHIBITORS | COGENT BIOSCIENCES, INC. (US) | 2025-02-06 | — | — | WO | disclosed |
| US-20240182460-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION | 2024-06-06 | — | — | US | disclosed |
| WO-2024097172-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PETRA PHARMA CORPORATION (US) | 2024-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250206752-A1 | PI3K INHIBITORS | PIK3CA, PIK3R5, PIK3R4 | ALDH1A1 4448/4885CYP2C9 1556/4885METAP1 4068/4885 |
| US-12281122-B1 | PI3K inhibitors | PIK3CA, PIK3R5, PIK3R4 | ALDH1A1 4448/4885CYP2C9 1556/4885METAP1 4068/4885 |
| US-20240182460-A1 | ALLOSTERIC CHROMENONE INHIBITORS OF PHOSPHOINOSITIDE 3-KINASE (PI3K) FOR THE TREATMENT OF DISEASE | PIK3CA, PIK3R4, PIK3R5 | ALDH1A1 3403/4885CYP2C9 822/4885METAP1 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.