Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.36 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | JAK1 | P23458 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 5/20 | 0.36 |
| ▸ | STAT3 | P40763 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 2/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29754196 | 0.89 | IGF1R (0.43) | JAK3JAK2JAK1TYK2CDK2 | |
| SCHEMBL27275335 | 0.89 | IGF1R (0.43) | JAK3JAK2JAK1TYK2CDK2 | |
| SCHEMBL28703864 | 0.87 | JAK1 (0.39) | JAK2JAK1TBK1BTKIGF1R | |
| SCHEMBL30891589 | 0.87 | GFER (0.39) | JAK3JAK2JAK1TYK2BTK | |
| SCHEMBL30956382 | 0.81 | JAK2 (0.53) | JAK3JAK2JAK1TYK2STAT3 | |
| SCHEMBL22546070 | 0.81 | TBK1 (0.47) | JAK3JAK2JAK1TYK2STAT3 | |
| SCHEMBL29754256 | 0.81 | TBK1 (0.47) | JAK3JAK2JAK1TYK2STAT3 | |
| SCHEMBL30956580 | 0.81 | CPT1A (0.39) | JAK3JAK2JAK1IGF1R | |
| SCHEMBL22544824 | 0.81 | IGF1R (0.48) | CDK2IGF1R | |
| SCHEMBL29754145 | 0.81 | IGF1R (0.48) | CDK2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702683-A | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-113993861-B | Phenyl ethers and anilines of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-05-14 | — | — | CN | disclosed |