Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1I | Q9P0X4 | 6/20 | 0.61 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.61 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.61 |
| ▸ | CNR2 | P34972 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PFKFB2 | O60825 | 1/20 | 0.35 |
| ▸ | PFKFB1 | P16118 | 1/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | HAT1 | O14929 | 2/20 | 0.34 |
| ▸ | EP300 | Q09472 | 2/20 | 0.34 |
| ▸ | IDH1 | O75874 | 2/20 | 0.34 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | RORA | P35398 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3095548 | 0.88 | CACNA1I (0.65) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3105419 | 0.87 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3102313 | 0.87 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3090917 | 0.87 | CACNA1I (0.64) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3099386 | 0.87 | CACNA1I (0.66) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3108545 | 0.84 | CACNA1I (0.60) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3098775 | 0.84 | CACNA1I (0.68) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3097034 | 0.82 | CACNA1I (0.63) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3101767 | 0.81 | CACNA1I (0.56) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 | |
| SCHEMBL3097144 | 0.81 | CACNA1I (0.67) | CACNA1ICACNA1HCACNA1GCNR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | claimed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | BARROW JAMES C | 2010-09-30 | — | — | US | disclosed |
| WO-2009054983-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | MERCK & CO., INC. (US) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249176-A1 | HETEROCYCLE AMIDE T-TYPE CALCIUM CHANNEL ANTAGONISTS | CACNA1G, CACNA1H, CACNA1I | CACNA1I 3/4885CACNA1H 2/4885CACNA1G 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.