Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30857796 | 0.90 | ESR2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL30857785 | 0.90 | ESR2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL24673913 | 0.84 | USP2 (0.51) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL10253506 | 0.84 | USP2 (0.51) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL18711868 | 0.83 | GRM5 (0.48) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL513246 | 0.83 | USP2 (0.50) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL1689676 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL3719620 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL2948300 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 | |
| SCHEMBL843458 | 0.81 | USP2 (0.49) | USP2SMN1; SMN2GRM5ESR2ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122029167-A | Condensed heteroaryl compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-119684315-B | Crystal form of benzothiophene substituted fused ring compound and preparation method thereof | 苏州盛迪亚生物医药有限公司 | 2026-05-12 | — | — | CN | disclosed |
| EP-4735451-A1 | SUBSTITUTED CONDENSED TRICYCLIC AMINE COMPOUNDS AND USES THEREOF AS RAS INHIBITORS | Kumquat Biosciences Inc. (US) | 2026-05-06 | — | — | EP | disclosed |
| EP-4635958-A1 | PYRIMIDINE-CONTAINING POLYCYCLIC DERIVATIVE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Hansoh Biomedical Co., Ltd. (CN) | 2025-10-22 | — | — | EP | disclosed |
| EP-4563580-A1 | FUSED RING COMPOUND, PREPARATION METHOD THEREFOR AND MEDICINAL APPLICATION THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2025-06-04 | — | — | EP | disclosed |
| WO-2025092798-A1 | FUSED HETEROARYL COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF IN MEDICINE | 江苏恒瑞医药股份有限公司 | 2025-05-08 | — | — | WO | disclosed |
| CN-119684316-A | Crystal form of benzothiophene substituted fused ring compound and preparation method thereof | 苏州盛迪亚生物医药有限公司 | 2025-03-25 | — | — | CN | disclosed |
| CN-119661556-A | Pharmaceutically acceptable salts of condensed ring compounds, crystalline forms and uses thereof | 苏州盛迪亚生物医药有限公司 | 2025-03-21 | — | — | CN | disclosed |
| CN-119661555-A | Pharmaceutically acceptable salts of condensed ring compounds, crystalline forms and uses thereof | 苏州盛迪亚生物医药有限公司 | 2025-03-21 | — | — | CN | disclosed |
| WO-2025059040-A1 | MUTANT KRAS MODULATORS AND USES THEREOF | NEWAVE PHARMACEUTICAL INC. (US) | 2025-03-20 | — | — | WO | disclosed |
| CN-119613432-A | Pharmaceutically acceptable salt of benzothiophene substituted fused ring compound, crystal form and application thereof | 苏州盛迪亚生物医药有限公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-119490512-A | Pharmaceutically acceptable salt of benzothiophene substituted fused ring compound, crystal form and application thereof | 苏州盛迪亚生物医药有限公司 | 2025-02-21 | — | — | CN | disclosed |
| CN-119365465-A | Condensed ring compound, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2025-01-24 | — | — | CN | disclosed |
| WO-2025007000-A1 | SUBSTITUTED CONDENSED TRICYCLIC AMINE COMPOUNDS AND USES THEREOF AS RAS INHIBITORS | KUMQUAT BIOSCIENCES INC. (US) | 2025-01-02 | — | — | WO | disclosed |
| WO-2024104453-A1 | FUSED TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL USE THEREOF | 江苏恒瑞医药股份有限公司 | 2024-05-23 | — | — | WO | disclosed |