SCHEMBL30898225

SCHEMBL30898225

CNc1nc(Cl)nc2c(Cc3cccc(C(F)(F)F)c3)[nH]nc12

nearest known ligand 0.73

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
YTHDC1 Q96MU7 6/20 0.73
YTHDF3 Q7Z739 2/20 0.73
YTHDF1 Q9BYJ9 2/20 0.73
YTHDF2 Q9Y5A9 2/20 0.73
MPO P05164 1/20 0.41
PPARG P37231 1/20 0.38
PPARD Q03181 1/20 0.38
KCNN3 Q9UGI6 1/20 0.38
TLR8 Q9NR97 1/20 0.37
TLR7 Q9NYK1 1/20 0.37
P2RX3 P56373 1/20 0.37
TDO2 P48775 1/20 0.36
APP P05067 1/20 0.36
CXCR2 P25025 1/20 0.36
IDH2 P48735 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30898260 0.85 YTHDC1 (0.78) YTHDC1YTHDF3YTHDF1YTHDF2MPO
SCHEMBL27387656 0.85 YTHDC1 (1.00) YTHDC1YTHDF3YTHDF1YTHDF2MPO
SCHEMBL30898232 0.85 YTHDC1 (1.00) YTHDC1YTHDF3YTHDF1YTHDF2MPO
SCHEMBL30898254 0.79 YTHDC1 (0.72) YTHDC1YTHDF3YTHDF1YTHDF2MPO
SCHEMBL30898241 0.70 YTHDC1 (0.62) YTHDC1YTHDF3YTHDF1YTHDF2
SCHEMBL20510977 0.68 APP (0.59) KCNN3TDO2APP
SCHEMBL28455003 0.67 TMIGD3 (0.50) PPARGPPARDKCNN3TDO2APP
SCHEMBL30898226 0.66 YTHDC1 (0.55) YTHDC1YTHDF3YTHDF1YTHDF2
SCHEMBL3237564 0.65 TAAR1 (0.64)
SCHEMBL9492711 0.64 HTR2C (0.48) MPOKCNN3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024105159-A1 LIGANDS OF THE M6A-RNA READERS UNIVERSITY OF ZURICH (CH) 2024-05-23 WO disclosed