Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 9/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27182421 | 1.00 | NPC1 (0.38) | NPC1MAPK1PTPN11NOTUMF2RL1 | |
| SCHEMBL26920610 | 0.82 | KDM4A (0.37) | PTPN11NOTUMGAAMAPTLMNA | |
| SCHEMBL29734926 | 0.82 | KDM4A (0.37) | PTPN11NOTUMGAAMAPTLMNA | |
| SCHEMBL30835350 | 0.74 | PTPN11 (0.47) | MAPK1PTPN11NOTUMLMNAKMT2A | |
| SCHEMBL27082924 | 0.74 | PTPN11 (0.47) | MAPK1PTPN11NOTUMLMNAKMT2A | |
| SCHEMBL24181741 | 0.73 | BMP4 (0.43) | NPC1PTPN11 | |
| SCHEMBL24181824 | 0.72 | PTPN11 (0.36) | PTPN11NOTUM | |
| SCHEMBL18319628 | 0.72 | PTPN11 (0.55) | PTPN11ALDH1A1 | |
| SCHEMBL24181578 | 0.71 | CNR2 (0.41) | PTPN11NOTUMALDH1A1LMNA | |
| SCHEMBL25395155 | 0.70 | NUDT1 (0.33) | PTPN11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4594324-A1 | AZOLE DERIVATIVES AS SHP2 INHIBITORS | IRBM S.P.A. (IT) | 2025-08-06 | — | — | EP | disclosed |
| CN-120129683-A | Azole derivatives as SHP2 inhibitors | IRBM股份公司 | 2025-06-10 | — | — | CN | disclosed |