Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL29352119 | 0.97 | — | — | |
| Propylene Glycol SCHEMBL28574118 | 0.97 | TDP1 (0.71) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL320017 | 0.97 | — | — | |
| Propylene Glycol SCHEMBL4337036 | 0.97 | TDP1 (0.71) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL28505248 | 0.90 | TDP1 (0.62) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL29212884 | 0.90 | TDP1 (0.62) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL28400237 | 0.88 | TDP1 (0.59) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL49092 | 0.87 | TDP1 (0.67) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL21828462 | 0.87 | TDP1 (0.67) | TDP1OR51E2TP53TSHRALDH1A1 | |
| Propylene Glycol SCHEMBL358822 | 0.87 | TDP1 (0.67) | TDP1OR51E2TP53TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790908-B2 | Process for preparing glyceryl carbonate | EVONIK ROEHM GMBH (DE) | 2010-09-07 | — | — | US | disclosed |
| US-20080255372-A1 | Process for Preparing Glyceryl Carbonate | EVONIK ROEHM GMBH (DE) | 2008-10-16 | — | — | US | disclosed |