Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.56 |
| ▸ | TFPI2 | P48307 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CPS1 | P31327 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28409121 | 0.78 | MTNR1A (0.55) | TUBB1TFPI2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL5569918 | 0.78 | TFPI2 (0.57) | TUBB1TFPI2MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL30297606 | 0.78 | TFPI2 (0.57) | TUBB1TFPI2MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL3917906 | 0.76 | TUBB1 (0.76) | TUBB1TFPI2MTNR1AMTNR1BAKR1C3 | |
| SCHEMBL28661147 | 0.76 | TFPI2 (0.52) | TUBB1TFPI2MTNR1AMTNR1BTRPV1 | |
| SCHEMBL20905149 | 0.73 | TFPI2 (0.50) | TUBB1TFPI2MTNR1AMTNR1BMEN1 | |
| SCHEMBL2117429 | 0.73 | MTNR1A (0.51) | TUBB1TFPI2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL6331989 | 0.73 | MAPT (0.51) | TUBB1TFPI2MTNR1AALDH1A1FABP4 | |
| SCHEMBL982760 | 0.72 | TFPI2 (0.49) | TUBB1TFPI2MTNR1AMTNR1BTRPV1 | |
| SCHEMBL3919337 | 0.72 | TUBB1 (1.00) | TUBB1TFPI2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795280-B2 | Indoles useful in the treatment of androgen-receptor related diseases | N.V. ORGANON (NL) | 2010-09-14 | — | — | US | disclosed |
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AKZO NOBEL N.V. (NL) | 2006-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060128722-A1 | Indoles useful in the treatment of androgen-receptor related diseases | AR, NR5A1, SHBG | TUBB1 737/4885TFPI2 2827/4885MTNR1A 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.