Citric Acid

Citric Acid

SCHEMBL309023

B.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O

nearest known ligand 0.94

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 1/20 0.41
ALDH1A1 P00352 2/20 0.94
HMGCR P04035 1/20 0.48
CHRM1 P11229 1/20 0.48
TBXA2R P21731 1/20 0.48
ADRA1A P35348 1/20 0.48
TSHR P16473 2/20 0.46
CYP2D6 P10635 2/20 0.46
CYP2C19 P33261 1/20 0.46
HIF1A Q16665 1/20 0.46
ACLY P53396 4/20 0.44
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
MAPT P10636 1/20 0.43
ALOX15 P16050 1/20 0.43
SLC13A5 Q86YT5 4/20 0.42
CPT2 P23786 1/20 0.42
CYP1A2 P05177 1/20 0.41
KMT2A Q03164 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Citric Acid SCHEMBL20579558 1.00 ALDH1A1 (0.94) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1155695 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1155227 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1155421 0.97 ALDH1A1 (0.88) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL240402 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1331942 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL3417188 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL10896997 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL842 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A
Citric Acid SCHEMBL1332229 0.97 ALDH1A1 (1.00) ALDH1A1HMGCRCHRM1TBXA2RADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122079762-A Preparation method of high-solubility boron citrate 2026-05-26 CN claimed
CN-116726141-B Composition for preventing and relieving osteoarthropathy and application thereof 华润圣海健康科技有限公司 2023-11-03 CN claimed
CN-116726141-A Composition for preventing and relieving osteoarthropathy and application thereof 华润圣海健康科技有限公司 2023-09-12 CN claimed
CN-114946988-A Method for inhibiting water outflow and sand return of candy without candy gel 艾兰得营养品泰州有限公司 2022-08-30 CN claimed
CN-114698716-A Method for inhibiting dissolution and retrogradation of multi-dimensional gel candy 艾兰得营养品泰州有限公司 2022-07-05 CN claimed
US-20220202757-A1 PROTEIN SUBSTITUTE AMINO ACID COMPOSITIONS AND PRODUCTS, AND OTHER FOOD AND BEVERAGE PRODUCTS MUNZER MARTIN (US) 2022-06-30 US claimed
EP-3666249-B1 COMPLEXES OF ORGANIC SILICON COMPOUNDS WITH BORON CITRATE AND DIMETHYLETHANOLAMINE JEDNOSTKA INNOWACYJNO WDROZENIOWA INWEX SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (PL) 2021-09-08 EP claimed
WO-2020210540-A2 NUTRIENT COMPOSITIONS AND METHODS FOR ADMINISTERING A NUTRIENT COMPOSITION MUNZER MARTIN (US) 2020-10-15 WO claimed
WO-2020210547-A1 PROTEIN SUBSTITUTE AMINO ACID COMPOSITIONS AND PRODUCTS, AND OTHER FOOD AND BEVERAGE PRODUCTS MUNZER MARTIN (US) 2020-10-15 WO claimed
EP-3666249-A1 COMPLEXES OF ORGANIC SILICON COMPOUNDS WITH BORON CITRATE AND DIMETHYLETHANOLAMINE Jednostka Innowacyjno-Wdrozeniowa INWEX Spolka z Ograniczona odpowiedzialnoscia (PL) 2020-06-17 EP claimed
US-6861073-B2 Dysfunctional satiety center syndrome and method of treatment therefor TAI PAUL LING (US) 2005-03-01 US claimed
US-20040202727-A1 Dysfunctional satiety center syndrome and method of treatment therefor TAI PAUL LING (US) 2004-10-14 US claimed
EP-1450776-A1 COMPOSITIONS AND KITS COMPRISING A DEFINED BORON COMPOUND, METHODS OF THEIR PREPARATION, AND USE AND ADMINISTRATION THEREOF THE PROCTER & GAMBLE COMPANY (US) 2004-09-01 EP claimed
US-6632449-B2 PH of the composition is at least about 3 pH units less than the pKa of the boron compound; antiinflammatory, osteoarthritis, analgesic; boric acid, boron citrate THE PROCTER & GAMBLE CO. 2003-10-14 US claimed
WO-2003043617-A1 COMPOSITIONS AND KITS COMPRISING A DEFINED BORON COMPOUND, METHODS OF THEIR PREPARATION, AND USE AND ADMINISTRATION THEREOF THE PROCTER & GAMBLE COMPANY (US) 2003-05-30 WO claimed
US-20030096794-A1 Compositions and kits comprising a defined boron compound, methods of their preparation, and use and administration thereof THE PROCTER & GAMBLE CO. 2003-05-22 US claimed
US-6447809-B1 MIXTURES OF MICROCRYSTALLINE HYDROXYAPATITE, CHOLECALCIFEROL AND IPRIFLAVONE ADMINISTERED AS OSTEOBLASTS STIMULANTS FOR PREVENTION OF OSTEOPOROSIS METAGENICS, INC. 2002-09-10 US claimed
WO-1998008524-A1 MULTIMINERAL PRODUCTS USEFUL IN ACHIEVING AUTONOMIC BALANCE GONZALEZ NICHOLAS JAMES (US) 1998-03-05 WO claimed
WO-1992012714-A2 FOOD SUPPLEMENT 1992-08-06 WO claimed
WO-1992012714-A1 FOOD SUPPLEMENT R.A. VAN DER KUIL HOLDING B.V. (NL) 1992-08-06 WO claimed