Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | HMGCR | P04035 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | ACLY | P53396 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CPT2 | P23786 | 1/20 | 0.44 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL6889857 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10896997 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL4958371 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL725546 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL842 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1332229 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28641702 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1331942 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3417188 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27588807 | 1.00 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11554085-B2 | Combar for skin and hair treatment | HENKEL AG & CO. KGAA (DE) | 2023-01-17 | — | — | US | claimed |
| CN-114588092-A | Relieving and anti-inflammatory cleansing oil and preparation method thereof | 中山中研化妆品有限公司 | 2022-06-07 | — | — | CN | claimed |
| US-20210015728-A1 | COMBAR FOR SKIN AND HAIR TREATMENT | HENKEL AG & CO. KGAA (DE) | 2021-01-21 | — | — | US | claimed |
| CN-111249193-A | Skin care oil and preparation method and application thereof | 广东丸美生物技术股份有限公司 | 2020-06-09 | — | — | CN | claimed |
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | HENKEL AG & CO. KGAA (DE) | 2012-01-26 | — | — | US | claimed |
| EP-0777422-B1 | PROCESS FOR PRODUCING A GEL-FORMING SUBSTANCE | PFEIFER & LANGEN (DE) | 2001-01-03 | — | — | EP | claimed |
| EP-0747340-B1 | Anhydrous trisodiumcitrate, process for its preparation and its use as carriers | JUNGBUNZLAUER AG (AT) | 1999-09-01 | — | — | EP | claimed |
| EP-0680747-B1 | Cosmetic and/or dermatologic composition containing a glycerol tri(alpha-hydroxyacylate) as sole precursor of glycerol | OREAL (FR) | 1998-07-01 | — | — | EP | claimed |
| EP-0680747-A1 | Cosmetic and/or dermatologic composition containing a glycerol tri(alpha-hydroxyacylate) as sole precursor of glycerol | L'OREAL (FR) | 1995-11-08 | — | — | EP | claimed |
| US-5157030-A | Adding lecithin polysorbate, glycerol monostearate, or polyether surfactant | SOLUPRIN PHARMACEUTICALS, INC. | 1992-10-20 | — | — | US | claimed |
| EP-0091163-B1 | POSITIVE-WORKING PHOTORESIST COMPOSITION AND METHOD FOR FORMING A LIGHT-ABSORBING MATRIX IN A COLOR CRT STRUCTURE | North American Philips Corporation (US) | 1987-11-25 | — | — | EP | claimed |
| CN-120059146-A | Method for preparing bio-based polyester-carbonate based on bio-based dicarboxylic acid carbonate | 沈阳工业大学 | 2025-05-30 | — | — | CN | disclosed |
| CN-113423470-B | Cosmetic compounding agent, cosmetic, and method for producing same | 三吉油脂株式会社 | 2024-07-09 | — | — | CN | disclosed |
| CN-114588092-B | Anti-inflammatory cleansing oil and preparation method thereof | 中山中研化妆品有限公司 | 2024-02-06 | — | — | CN | disclosed |
| CN-116940351-A | Prodrug compositions and methods of treatment | 阿奎斯蒂弗医疗股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| WO-1993016187-A1 | PLANT CARRYING GENES CODING FOR ENZYMES OF THE PHYTOSTEROL BIOSYNTHESIS PATHWAY AND PROCESS FOR THE PRODUCTION OF SAME | VERNEUIL RECHERCHE (FR) | 1993-08-19 | — | — | WO | disclosed |
| US-5223302-A | Ground meat containing water and specially prepared calcium citrate salt | KRAFT GENERAL FOODS, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5175087-A | Introducing blood into container with acidic buffer | BIOPOOL INTERNATIONAL, INC. (US) | 1992-12-29 | — | — | US | disclosed |
| WO-1992013884-A1 | LIVER-STAGE-SPECIFIC PEPTIDE SEQUENCES OF P. FALCIPARUM BEARING EPITOPES CAPABLE OF STIMULATING THE T LYMPHOCYTES | INSTITUT PASTEUR (FR) | 1992-08-20 | — | — | WO | disclosed |
| US-4330459-A | Method of manufacturing foundry sand molds | KURARAY COMPANY, LTD. (JP) | 1982-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120020906-A1 | ANTIPERSPIRANT SPRAYS WITH ESTER OILS | CUTA, NAPEPLD, LIPE | MEN1 2309/4885ALDH1A1 1032/4885HMGCR 359/4885 |
| US-20210015728-A1 | COMBAR FOR SKIN AND HAIR TREATMENT | CUTA, POLR1C, CS | MEN1 2225/4885ALDH1A1 1999/4885HMGCR 193/4885 |
| US-11554085-B2 | Combar for skin and hair treatment | CUTA, POLR1C, CS | MEN1 2225/4885ALDH1A1 1999/4885HMGCR 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.