SCHEMBL30906236

SCHEMBL30906236

CC(C)(C)OC(=O)N1CCN(c2ccc(C#CCCCO)cn2)CC1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 1/20 0.54
▸ GPR119 Q8TDV5 5/20 0.49
▸ MAP4K4 O95819 1/20 0.47
▸ CKS1B P61024 2/20 0.46
▸ SKP1 P63208 2/20 0.46
▸ SKP2 Q13309 2/20 0.46
▸ DDB1 Q16531 1/20 0.46
▸ CRBN Q96SW2 1/20 0.46
▸ RET P07949 6/20 0.45
▸ HPGD P15428 1/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ WNT3A P56704 1/20 0.43
▸ PANK3 Q9H999 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30906197 0.87 ADK (0.56) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL5916462 0.82 ADK (0.58) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL3554489 0.80 PANK3 (0.63) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL5916431 0.80 ADK (0.56) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL30546362 0.80 PANK3 (0.63) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL20120820 0.80 GPR119 (0.58) GPR119MAP4K4CKS1BSKP1SKP2
SCHEMBL29773872 0.80 GPR119 (0.58) GPR119MAP4K4CKS1BSKP1SKP2
SCHEMBL30906326 0.78 GPR119 (0.62) GPR119MAP4K4CKS1BSKP1SKP2
SCHEMBL5916500 0.78 GRM5 (0.57) ADKGPR119MAP4K4CKS1BSKP1
SCHEMBL3975617 0.77 GPR119 (0.60) GPR119MAP4K4CKS1BSKP1SKP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598905-A2 CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS University of Florida Research Foundation, Incorporated (US) 2025-08-13 — — EP disclosed
WO-2024077023-A2 CEREBLON-RECRUITING BCL-XL/BCL-2 DUAL DEGRADERS UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED (US) 2024-04-11 — — WO disclosed
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