Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.47 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.39 |
| ▸ | CACNA1H | O95180 | 3/20 | 0.39 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30907586 | 0.80 | KDM1A (0.55) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL30907201 | 0.76 | AURKA (0.37) | HDAC1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL30907364 | 0.75 | KDM1A (0.39) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL30907612 | 0.74 | KDM1A (0.39) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL30502867 | 0.74 | KDM1A (0.54) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL29033973 | 0.74 | KDM1A (0.54) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL14896247 | 0.73 | CACNA1G (0.49) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL20518850 | 0.72 | JMJD6 (0.44) | KMT2ANPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL1196573 | 0.72 | KDM4E (0.51) | HDAC1KDM1AHDAC2HDAC8HDAC6 | |
| SCHEMBL4307777 | 0.71 | CACNA1G (0.54) | HDAC1KDM1AHDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024097953-A1 | NAPHTHYRIDINE COMPOUNDS FOR INHIBITION OF RAF KINASES | ENLIVEN INC. (US) | 2024-05-10 | — | — | WO | disclosed |