Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 20/20 | 0.52 |
| ▸ | HTR1D | P28221 | 10/20 | 0.51 |
| ▸ | HTR1B | P28222 | 10/20 | 0.51 |
| ▸ | HTR1A | P08908 | 9/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL7011859 | 1.00 | HTR1F (0.52) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| Fumaric Acid SCHEMBL7480212 | 0.87 | HTR1D (0.49) | HTR1DHTR1B | |
| Fumaric Acid SCHEMBL30909090 | 0.87 | HTR1D (0.49) | HTR1DHTR1B | |
| Fumaric Acid SCHEMBL7011854 | 0.84 | HTR1F (0.52) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7015069 | 0.76 | HTR1F (0.57) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013501 | 0.76 | HTR1F (0.65) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL7013905 | 0.75 | HTR1F (0.70) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8457509 | 0.74 | HTR1F (0.62) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| Malonic Acid SCHEMBL7006538 | 0.74 | HTR1F (0.58) | HTR1FHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8458326 | 0.73 | HTR1F (0.68) | HTR1FHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073845-A1 | METHODS AND PHARMACOLOGICAL AGENTS FOR INCREASING EXPANSION, ENGRAFTMENT OR IMMUNE OUTPUT OF HUMAN HEMATOPOIETIC STEM CELLS IN TRANSPLANTATION AND DISEASE SETTINGS | VALORISATION HSJ, LIMITED PARTNERSHIP (CA) | 2024-04-11 | — | — | WO | disclosed |