Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30911548 | 0.75 | — | — | |
| SCHEMBL30994018 | 0.71 | ALDH1A1 (0.40) | POLBALDH1A1KDM4EIRAK4HSD17B10 | |
| SCHEMBL4384536 | 0.71 | ALDH1A1 (0.40) | POLBALDH1A1KDM4EIRAK4HSD17B10 | |
| SCHEMBL593901 | 0.71 | POLB (0.42) | POLBALDH1A1KDM4EIRAK4TACR1 | |
| SCHEMBL16443770 | 0.70 | HCAR3 (0.35) | ALDH1A1 | |
| SCHEMBL17849522 | 0.69 | KMT2A (0.33) | ALDH1A1TYK2 | |
| SCHEMBL20565190 | 0.69 | TACR1 (0.43) | POLBALDH1A1KDM4EIRAK4TACR1 | |
| SCHEMBL7992753 | 0.68 | POLB (0.42) | POLBALDH1A1LMNA | |
| SCHEMBL5883439 | 0.68 | POLB (0.46) | POLBALDH1A1KDM4ETACR1TACR3 | |
| SCHEMBL31262723 | 0.67 | MAP4K4 (0.31) | JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117980297-A | Substituted aminopyridine compounds as EGFR inhibitors | 柳韩洋行 | 2024-05-03 | — | — | CN | disclosed |