Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30912595 | 1.00 | MAPT (0.49) | MAPTKDM4ERAD52ALDH1A1HTT | |
| SCHEMBL30912529 | 0.83 | MAPT (0.45) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL3413859 | 0.83 | MAPT (0.45) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL13657915 | 0.83 | MAPT (0.45) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL30912434 | 0.83 | MAPT (0.45) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL30912607 | 0.76 | ALDH1A1 (0.51) | MAPTALDH1A1HTTSMN1; SMN2GAA | |
| SCHEMBL21641736 | 0.76 | KCNH2 (0.44) | MAPTKDM4EALDH1A1GAACHRNA7 | |
| SCHEMBL27393647 | 0.76 | KCNH2 (0.44) | MAPTKDM4EALDH1A1GAACHRNA7 | |
| SCHEMBL2729685 | 0.76 | KCNH2 (0.44) | MAPTKDM4EALDH1A1GAACHRNA7 | |
| SCHEMBL14642921 | 0.73 | MAPT (0.44) | MAPTKDM4ERAD52ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4619406-A1 | TRICYCLIC COMPOUNDS | Schrödinger, Inc. (US) | 2025-09-24 | — | — | EP | disclosed |
| WO-2024107393-A1 | TRICYCLIC COMPOUNDS | SCHRÖDINGER, INC. (US) | 2024-05-23 | — | — | WO | disclosed |