Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.35 |
| ▸ | AKT1 | P31749 | 5/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL30916021 | 0.91 | LMNA (0.35) | LMNAHSD17B10RAB9AMAPK10SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL30916049 | 0.91 | DHODH (0.36) | LMNAHSD17B10RAB9AMAPK10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL29828357 | 0.86 | SCN4A (0.39) | PDPK1RPS6KB1AKT1PLA2G2ADHODH | |
| Hydrochloric Acid SCHEMBL29097073 | 0.86 | SCN4A (0.39) | PDPK1RPS6KB1AKT1PLA2G2ADHODH | |
| Hydrochloric Acid SCHEMBL29828403 | 0.86 | SCN4A (0.39) | PDPK1RPS6KB1AKT1PLA2G2ADHODH | |
| Hydrochloric Acid SCHEMBL29096946 | 0.86 | SCN4A (0.39) | PDPK1RPS6KB1AKT1PLA2G2ADHODH | |
| Hydrochloric Acid SCHEMBL29096949 | 0.86 | SCN4A (0.39) | PDPK1RPS6KB1AKT1PLA2G2ADHODH | |
| Hydrochloric Acid SCHEMBL30916089 | 0.85 | LMNA (0.36) | LMNAHSD17B10RAB9AMAPK10SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30916051 | 0.85 | AKT1 (0.36) | LMNAHSD17B10RAB9AMAPK10SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL30916066 | 0.83 | PPARG (0.33) | LMNAHSD17B10RAB9AMAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260098060-A1 | MACROCYCLIC CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2026-04-09 | — | — | US | disclosed |
| EP-4587443-A1 | MACROCYCLIC CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2025-07-23 | — | — | EP | disclosed |
| WO-2024056798-A1 | MACROCYCLIC CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260098060-A1 | MACROCYCLIC CFTR MODULATORS | CFTR, CLIC1, ARRB1 | LMNA 2343/4885HSD17B10 2897/4885RAB9A 1593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.