Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 3/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30917621 | 0.81 | LMNA (0.40) | NUDT1KDM4ELMNAKMT2AMAPK1 | |
| SCHEMBL30915372 | 0.70 | MEN1 (0.53) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30915355 | 0.70 | KMT2A (0.50) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL18304964 | 0.70 | KMT2A (0.38) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL31451764 | 0.68 | ALDH1A1 (0.50) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30915340 | 0.68 | MEN1 (0.50) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30915336 | 0.68 | MEN1 (0.47) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30915376 | 0.68 | KDM4E (0.40) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30915345 | 0.67 | KDM4E (0.41) | KDM4ELMNAKMT2AMAPK1MEN1 | |
| SCHEMBL30848372 | 0.66 | LMNA (0.43) | KDM4ELMNAKMT2AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4622716-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-10-01 | — | — | EP | disclosed |
| WO-2025038936-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-02-20 | — | — | WO | disclosed |
| WO-2024112654-A1 | SPIROCYCLIC DIHYDROPYRANOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-05-30 | — | — | WO | disclosed |