SCHEMBL30919482

SCHEMBL30919482

COC(=O)N(Cc1ccc(C)cc1C)NC(=O)c1cc(C)nnc1Oc1cccc(Cl)c1F

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 6/20 0.37
GCK P35557 1/20 0.34
HIF1A Q16665 1/20 0.32
ABCB1 P08183 1/20 0.32
MAPK8 P45983 1/20 0.31
CD38 P28907 1/20 0.30
F2 P00734 1/20 0.30
F3 P13726 1/20 0.30
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30
TP53 P04637 1/20 0.30
ALOX15 P16050 1/20 0.30
TSHR P16473 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
MAPT P10636 2/20 0.30
POLQ O75417 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
THRB P10828 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30919474 0.85 GCK (0.35) SCN9AGCKMAPK8
SCHEMBL30919494 0.83 SCN9A (0.33) SCN9AGCK
SCHEMBL30919473 0.81 NR3C1 (0.35) ABCB1ALDH1A1LMNATP53ALOX15
SCHEMBL30919475 0.80 MEN1 (0.31) LMNA
SCHEMBL30919498 0.79 MEN1 (0.30) LMNA
SCHEMBL31718970 0.79 MEN1 (0.30) LMNA
SCHEMBL31719026 0.79 MEN1 (0.30) LMNA
SCHEMBL30919503 0.79 SYK (0.31)
SCHEMBL30919497 0.77 CETP (0.31)
SCHEMBL31414003 0.73 NOTUM (0.45) SCN9AGCKF3TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024143336-A1 HYDRAZIDE COMPOUND AND AGRICULTURAL/HORTICULTURAL BACTERICIDAL AGENT 日本曹達株式会社 2024-07-04 WO disclosed