Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | KRAS | P01116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30922614 | 0.96 | DGAT2 (0.33) | DGAT2SMYD2RXRARXRBRXRG | |
| SCHEMBL30922972 | 0.90 | RXRA (0.31) | DGAT2RXRARXRBRXRGKRAS | |
| SCHEMBL30922623 | 0.88 | RXRA (0.31) | DGAT2RXRARXRBRXRGKRAS | |
| SCHEMBL30923059 | 0.87 | RXRA (0.33) | SMYD2RXRARXRBRXRG | |
| SCHEMBL30922878 | 0.85 | RXRA (0.32) | DGAT2RXRARXRBRXRGKRAS | |
| SCHEMBL30922414 | 0.82 | RXRA (0.32) | RXRARXRBRXRGKRAS | |
| SCHEMBL30922742 | 0.81 | RXRA (0.35) | DGAT2RXRARXRBRXRG | |
| SCHEMBL30922553 | 0.81 | KRAS (0.36) | DGAT2RXRARXRBRXRGKRAS | |
| SCHEMBL30922645 | 0.81 | RXRA (0.39) | DGAT2RXRARXRBRXRG | |
| SCHEMBL30922510 | 0.80 | CYP4F2 (0.33) | RXRARXRBRXRGKRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4598921-A1 | MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE | Amgen Inc. (US) | 2025-08-13 | — | — | EP | disclosed |
| WO-2024107686-A1 | MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2024-05-23 | — | — | WO | disclosed |