Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.56 |
| ▸ | CD38 | P28907 | 2/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | PRF1 | P14222 | 1/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 4/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CCNH | P51946 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685078 | 1.00 | CHEK1 (0.56) | CHEK1CHEK2CD38MKNK1MKNK2 | |
| SCHEMBL31125568 | 0.86 | KMO (0.55) | CHEK1CHEK2ERN1DYRK1AAXL | |
| SCHEMBL942184 | 0.86 | KMO (0.55) | CHEK1CHEK2ERN1DYRK1AAXL | |
| SCHEMBL31173737 | 0.85 | CHEK2 (0.67) | CHEK1CHEK2CD38MKNK1MKNK2 | |
| SCHEMBL21826334 | 0.81 | CA12 (0.50) | ERN1CDK8AXL | |
| Hydrochloric Acid SCHEMBL6244513 | 0.80 | GABRG2 (0.49) | ERN1CDK8AXL | |
| SCHEMBL28954593 | 0.77 | KDM4B (0.55) | CHEK1CHEK2CD38MKNK1MKNK2 | |
| SCHEMBL29725591 | 0.76 | CHEK2 (0.53) | CHEK1CHEK2CD38MYCLRRK2 | |
| SCHEMBL4559856 | 0.76 | AR (0.52) | CHEK1CHEK2PRF1PARP1 | |
| SCHEMBL2431097 | 0.75 | PARP1 (0.64) | ERN1CCNT1CCND1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615825-A1 | INHIBITORS OF CYCLIC ADP RIBOSE HYDROLASE METHODS OF USE THEREOF | Flagship Pioneering Innovations VI, LLC (US) | 2025-09-17 | — | — | EP | disclosed |
| WO-2024102922-A1 | INHIBITORS OF CYCLIC ADP RIBOSE HYDROLASE METHODS OF USE THEREOF | FLAGSHIP PIONEERING INNOVATIONS, VI, LLC (US) | 2024-05-16 | — | — | WO | disclosed |