SCHEMBL30929477

SCHEMBL30929477

Cc1cc(C)cc(CNc2cnc3n(c2=O)[C@H](C(=O)NCc2cnc4c(c2)CNC4)CC3)c1

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F2 P00734 5/20 0.49
F7 P08709 5/20 0.49
F3 P13726 5/20 0.49
KMT2A Q03164 1/20 0.35
CYP3A4 P08684 2/20 0.34
CYP2C9 P11712 2/20 0.34
CYP2C19 P33261 2/20 0.34
F10 P00742 2/20 0.33
P2RX7 Q99572 3/20 0.33
PREP P48147 3/20 0.32
AADAT Q8N5Z0 1/20 0.32
WDR5 P61964 1/20 0.31
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30929405 0.95 F2 (0.46) F2F7F3KMT2ACYP3A4
Trifluoroacetic Acid SCHEMBL30929401 0.95 F2 (0.45) F2F7F3KMT2ACYP3A4
SCHEMBL30929408 0.84 F2 (0.46) F2F7F3KMT2ACYP3A4
SCHEMBL31486431 0.84 F2 (0.34) F2F7F3KMT2ACYP3A4
SCHEMBL30929426 0.82 F2 (0.52) F2F7F3KMT2ACYP3A4
SCHEMBL30929430 0.82 F2 (0.44) F2F7F3KMT2ACYP3A4
SCHEMBL30929436 0.82 F2 (0.57) F2F7F3KMT2ACYP3A4
SCHEMBL30929414 0.82 F2 (0.48) F2F7F3KMT2ACYP3A4
SCHEMBL30929412 0.81 F2 (0.54) F2F7F3KMT2ACYP3A4
SCHEMBL30929399 0.79 F2 (0.47) F2F7F3KMT2ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4626891-A1 FUSED PYRIMIDINES AS MASP-2 INHIBITORS Omeros Corporation (US) 2025-10-08 EP disclosed
WO-2024118840-A1 FUSED PYRIMIDINES AS MASP-2 INHIBITORS OMEROS CORPORATION (US) 2024-06-06 WO disclosed