Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.48 |
| ▸ | MDH1 | P40925 | 1/20 | 0.48 |
| ▸ | MDH2 | P40926 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.48 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1138925 | 0.92 | EPHX2 (0.59) | EPHX2TRPV1MAPTCYP17A1LMNA | |
| SCHEMBL29131710 | 0.89 | HPGD (0.59) | MAPTHPGDSMN1; SMN2CYP17A1PDK1 | |
| SCHEMBL20469627 | 0.88 | MEN1 (0.53) | TRPV1MAPTHPGDSMN1; SMN2MAPK14 | |
| SCHEMBL20865537 | 0.88 | HPGD (0.51) | HPGDSMN1; SMN2MAPK14CYP17A1PDK1 | |
| SCHEMBL20865538 | 0.84 | CYP17A1 (0.59) | HPGDSMN1; SMN2CYP17A1PDK1PDK2 | |
| SCHEMBL23637726 | 0.84 | CYP17A1 (0.63) | HPGDSMN1; SMN2BRAFKDRMAPK14 | |
| SCHEMBL29131712 | 0.83 | HPGD (0.71) | MAPTHPGDSMN1; SMN2MAPK14PDK1 | |
| SCHEMBL23966382 | 0.83 | HPGD (0.53) | HPGDSMN1; SMN2MAPK14CYP17A1LMNA | |
| SCHEMBL31483499 | 0.82 | ALDH1A1 (0.52) | HPGDSMN1; SMN2CYP17A1 | |
| SCHEMBL1853151 | 0.82 | CYP17A1 (0.54) | EPHX2TRPV1MAPTSMN1; SMN2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4626865-A1 | CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS | Protego Biopharma, Inc. (US) | 2025-10-08 | — | — | EP | disclosed |
| WO-2024118810-A1 | CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS | PROTEGO BIOPHARMA, INC. (US) | 2024-06-06 | — | — | WO | disclosed |