Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | TDO2 | P48775 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649008 | 1.00 | NTRK1 (0.47) | NTRK1EGFRIDO1TDO2CCNC | |
| SCHEMBL13649055 | 0.90 | EGFR (0.44) | NTRK1EGFRCDK8RPS6KB1MEN1 | |
| SCHEMBL14662047 | 0.86 | EGFR (0.46) | NTRK1EGFRCCNCCDK8LMNA | |
| SCHEMBL14662045 | 0.86 | EGFR (0.46) | NTRK1EGFRCCNCCDK8LMNA | |
| SCHEMBL14670573 | 0.86 | EGFR (0.46) | NTRK1EGFRCCNCCDK8LMNA | |
| SCHEMBL14670665 | 0.84 | EGFR (0.45) | NTRK1EGFRCCNCCDK8LMNA | |
| SCHEMBL14670658 | 0.84 | EGFR (0.45) | NTRK1EGFRCCNCCDK8LMNA | |
| SCHEMBL14670585 | 0.84 | USP1 (0.51) | EGFRCCNCCDK8LMNAHPGD | |
| SCHEMBL30930030 | 0.84 | USP1 (0.51) | EGFRCCNCCDK8LMNAHPGD | |
| SCHEMBL14670663 | 0.84 | USP1 (0.51) | EGFRCCNCCDK8LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118084892-A | Compounds useful as HPK1 inhibitors | 深圳福沃药业有限公司 | 2024-05-28 | — | — | CN | disclosed |