Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 9/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 9/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3260895 | 0.88 | CA9 (0.47) | PRMT5WDR77CA9CA12KDM4E | |
| SCHEMBL20227576 | 0.85 | PARP1 (0.44) | PRMT5WDR77CA9CA12KDM4E | |
| SCHEMBL1226551 | 0.84 | LPL (0.42) | PRMT5WDR77CA9CA12CSF1R | |
| SCHEMBL20227726 | 0.83 | PARP1 (0.47) | PRMT5WDR77KDM4EPARP1ALDH1A1 | |
| SCHEMBL19896283 | 0.82 | LPL (0.46) | PRMT5WDR77CA9CA12CSF1R | |
| SCHEMBL20227582 | 0.79 | PRMT5 (0.46) | PRMT5WDR77CA9CA12KDM4E | |
| SCHEMBL20227578 | 0.76 | PARP1 (0.50) | PRMT5WDR77CA9CA12KDM4E | |
| SCHEMBL20227583 | 0.76 | PARP1 (0.50) | PRMT5WDR77CA9CA12KDM4E | |
| SCHEMBL9891366 | 0.76 | KIF11 (0.49) | PRMT5WDR77ALDH1A1LPLLIPG | |
| SCHEMBL30041886 | 0.75 | KDM4E (0.47) | PRMT5WDR77CA9CA12KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024125464-A1 | TETRAHYDROISOQUINOLIN-ONE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) | 2024-06-20 | — | — | WO | disclosed |