Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 8/20 | 0.36 |
| ▸ | LMNA | P02545 | 5/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | STAT3 | P40763 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.35 |
| ▸ | NPC1 | O15118 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30964035 | 1.00 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1NPSR1TSHRLMNA | |
| SCHEMBL30964056 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2TDP1NPSR1TSHRLMNA | |
| SCHEMBL30964043 | 0.83 | S1PR1 (0.36) | SMN1; SMN2TSHRLMNAS1PR1NPC1 | |
| SCHEMBL30935593 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2TDP1NPSR1TSHRLMNA | |
| SCHEMBL30935604 | 0.71 | SMN1; SMN2 (0.42) | SMN1; SMN2TDP1NPSR1TSHRLMNA | |
| SCHEMBL31261554 | 0.71 | RAB9A (0.66) | SMN1; SMN2TDP1TSHRLMNAS1PR1 | |
| SCHEMBL30935486 | 0.71 | SCN5A (0.44) | SMN1; SMN2TDP1NPSR1TSHRLMNA | |
| SCHEMBL14741547 | 0.67 | MAPT (0.45) | SMN1; SMN2TDP1TSHRLMNAS1PR1 | |
| SCHEMBL14741772 | 0.67 | TP53 (0.44) | SMN1; SMN2TDP1TSHRLMNAHTT | |
| SCHEMBL31261570 | 0.67 | NPSR1 (0.43) | SMN1; SMN2TDP1NPSR1TSHRS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |