Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30935604 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2NPSR1TDP1SCN5ASCN10A | |
| SCHEMBL30935486 | 0.86 | SCN5A (0.44) | SMN1; SMN2NPSR1TDP1SCN5ASCN10A | |
| SCHEMBL14741792 | 0.78 | HDAC8 (0.41) | SMN1; SMN2TDP1S1PR1NPC1HTT | |
| SCHEMBL14739607 | 0.77 | MAPT (0.55) | HTTMAPTTSHRTP53 | |
| SCHEMBL30964035 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2NPSR1TDP1S1PR1NPC1 | |
| SCHEMBL30935640 | 0.74 | SMN1; SMN2 (0.42) | SMN1; SMN2NPSR1TDP1S1PR1NPC1 | |
| SCHEMBL14741772 | 0.74 | TP53 (0.44) | SMN1; SMN2TDP1S1PR1NPC1HTT | |
| SCHEMBL14741559 | 0.74 | TP53 (0.50) | SMN1; SMN2NPC1HTTRAB9ALMNA | |
| SCHEMBL31261554 | 0.73 | RAB9A (0.66) | SMN1; SMN2TDP1S1PR1NPC1RAB9A | |
| SCHEMBL30935565 | 0.73 | RAB9A (0.66) | SMN1; SMN2TDP1S1PR1NPC1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4630424-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | Third Harmonic Bio, Inc. (US) | 2025-10-15 | — | — | EP | disclosed |
| WO-2024124002-A1 | COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS | THIRD HARMONIC BIO, INC. (US) | 2024-06-13 | — | — | WO | disclosed |